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FLASH GENE
Symbol ACSBG1 contributors: npt - updated : 03-03-2010
HGNC name acyl-CoA synthetase bubblegum family member 1
HGNC id 29567
Location 15q25.1      Physical location : 78.463.188 - 78.526.899
Synonym name
  • lipidosin
  • bubblegum
  • very long-chain acyl-CoA synthetase
  • ortholog of rodent gonadotropin-regulated long chain acyl-CoA synthetase
  • Synonym symbol(s) KIAA0631, BG1, BGM, GR-LACS, FLJ30320, MGC14352, hsBG
    EC.number 6.2.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 63.71 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2867 80 724 brain, spinal cord, testis Jia (2004)
    - - 1213 - - ovary and adrenal gland Jia (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Drosophila lipidosin
    homolog to murine Acsbg1
    intraspecies homolog to mycobacterium T long-chain-fatty-acid CoA ligase
    Homologene
    FAMILY
  • ATP-dependent AMP-binding enzyme family
  • bubblegum subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • long-chain acyl-CoA synthetase activity
  • playing a central role in brain very long-chain fatty acids metabolism and myelinogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in adrenoleukodystrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS