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FLASH GENE

Symbol

ACSBG1

contributors: mct - updated : 27-12-2021

HGNC name	acyl-CoA synthetase bubblegum family member 1
HGNC id	29567

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q25.1      Physical location : 78.463.188 - 78.526.899
Synonym name	lipidosin
	bubblegum
	very long-chain acyl-CoA synthetase
	ortholog of rodent gonadotropin-regulated long chain acyl-CoA synthetase
Synonym symbol(s)	KIAA0631, BG1, BGM, GR-LACS, FLJ30320, MGC14352, hsBG
EC.number	6.2.1.3

DNA

TYPE	functioning gene
STRUCTURE	67.16 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015162 14 - 6215 NP_055977 80 724 brain, spinal cord, testis 2006 16371355 NM_001199377 14 - 6203 NP_001186306 - 720 ovary and adrenal gland 2006 16371355

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Nervous brain       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to Drosophila lipidosin
	homolog to murine Acsbg1

intraspecies

homolog to mycobacterium T long-chain-fatty-acid CoA ligase

Homologene

FAMILY	ATP-dependent AMP-binding enzyme family
	bubblegum subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	long-chain acyl-CoA synthetase activity
	playing a central role in brain very long-chain fatty acids metabolism and myelinogenesis
	ACSBG1, ACSBG2 are ACSBG gene family which activates, Fatty acids (FAs) with >16 carbons
	acyl-CoA synthetase, being the key pro-ferroptotic factor in the heat-induced ferroptosis proces

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in adrenoleukodystrophy tumoral         aberrant promoter methylation might be involved in its silencing/expression in malignant pheochromocytoma (PCC) and paraganglioma (PGL)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS