Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACSBG1 contributors: mct - updated : 27-12-2021
HGNC name acyl-CoA synthetase bubblegum family member 1
HGNC id 29567
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Drosophila lipidosin
homolog to murine Acsbg1
intraspecies homolog to mycobacterium T long-chain-fatty-acid CoA ligase
Homologene
FAMILY
  • ATP-dependent AMP-binding enzyme family
  • bubblegum subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • long-chain acyl-CoA synthetase activity
  • playing a central role in brain very long-chain fatty acids metabolism and myelinogenesis
  • ACSBG1, ACSBG2 are ACSBG gene family which activates, Fatty acids (FAs) with >16 carbons
  • acyl-CoA synthetase, being the key pro-ferroptotic factor in the heat-induced ferroptosis proces
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in adrenoleukodystrophy
    tumoral        
    aberrant promoter methylation might be involved in its silencing/expression in malignant pheochromocytoma (PCC) and paraganglioma (PGL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS