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FLASH GENE

Symbol

ACR

contributors: mct - updated : 21-01-2025

HGNC name	acrosin
HGNC id	126

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPGF87 spermatogenic failure 87
Location	22q13.33      Physical location : 51.176.651 - 51.183.726
Synonym name	preproacrosin
	proacrosin
Synonym symbol(s)	sp32, SPGF87
EC.number	3.4.21.10

DNA

TYPE	functioning gene
STRUCTURE	7.14 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001097 5 - 1430 NP_001088 - 421 - 2019 30428044

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary         male system testis

cell lineage	sperm cells-postmeiotic stages of sperms
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	acrosome

basic FUNCTION	serine proteinase with trypsin-like specificity
	major proteinase present in the acrosome of mature spermatozoa
	function both in the limited proteolysis of the zona pellucida, and in the maintenance of binding of acrosome-reacted sperm to the zona
	having functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum
	MMP2 and ACR are associated with the inner acrosomal membrane (IAM) and introduces the possibility of their cooperation in enzymatic digestion of the Sperm-zona pellucida (ZP) during penetration
	role of acrosin in acrosome exocytosis and activation of other acrosome components
	trypsin-like serine protease in the sperm acrosome

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

text	lysis of the zona pellucida

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF87

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function is associated with sperm function anomaly and poor outcomes of in vitro fertilization

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   is an attractive target for the discovery of novel male contraceptives

ANIMAL & CELL MODELS

	KO acrosin-deficient mice exhibit normal fecundity except for delayed fertilization
	litter size from acrosin-disrupted males was decreased compared to heterozygous mutant rats