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FLASH GENE
Symbol ACR contributors: mct - updated : 09-02-2008
HGNC name acrosin
HGNC id 126
Location 22q13.33      Physical location : 51.176.651 - 51.183.726
Synonym name
  • preproacrosin
  • proacrosin
  • Synonym symbol(s) sp32
    EC.number 3.4.21.10
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1384 - 421 - Dube (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage sperm cells-postmeiotic stages of sperms
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text acrosome
    basic FUNCTION
  • serine proteinase with trypsin-like specificity
  • major proteinase present in the acrosome of mature spermatozoa
  • function both in the limited proteolysis of the zona pellucida, and in the maintenance of binding of acrosome-reacted sperm to the zona
  • having functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text lysis of the zona pellucida
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS