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FLASH GENE

Symbol

ABI2

contributors: KTN/npt - updated : 04-02-2009

HGNC name	abl interactor 2
HGNC id	24011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q33.2      Physical location : 204.193.002 - 204.296.891
Synonym name	arg protein tyrosine kinase-binding protein
	abl binding protein 3
	p53-regulated apoptosis inducing protein 1
	Abelson interactor 2
	Arg-binding protein 1
Synonym symbol(s)	ABLIP, ABI2B, AIP-1, AblBP3, argBPIA, ABI-2, SSH3BP2, argBPIB, ArgBP1

DNA

TYPE	functioning gene
STRUCTURE	103.89 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D2S346 - D2S2289 - ABI2 - D2S307 - D2S2189 - qter
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ABI2 10 - 6489 52.3 475 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Nervous brain       predominantly Reproductive female system breast mammary gland       male system testis     predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines	isolated from a lymphocyte library
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a t-SNARE coiled-coil homology domain
	an SH3 domain
	several polyproline stretches, proline-rich sequences critical for binding to c-Abl

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Abi2 (98.9 pc)
	homolog to murine Abi2 (99.3 pc)

Homologene

FAMILY

ABI family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	localized in lamellipodia and filopodia (Stradal 2001)

basic FUNCTION	may be functioning as a tumor suppressor (Dai 1995)
	may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2 (Dai 1995)
	may be involved in cytoskeletal reorganization (Stradal 2001)
	involved in actin polymerization or depolymerization
	regulating ABL1/c-Abl-mediated phosphorylation of EGFR (Hirao 2006)
	being a SH3/SH2 adaptor

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with ABL1 and ABL2 (Dai 1995)
	binding to TRIM32 (Kano 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS