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FLASH GENE
Symbol ABI2 contributors: KTN/npt - updated : 04-02-2009
HGNC name abl interactor 2
HGNC id 24011
DNA
TYPE functioning gene
STRUCTURE 103.89 kb     10 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D2S346 - D2S2289 - ABI2 - D2S307 - D2S2189 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6489 52.3 475 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Nervousbrain   predominantly
Reproductivefemale systembreastmammary gland  
 male systemtestis  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines isolated from a lymphocyte library
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a t-SNARE coiled-coil homology domain
  • an SH3 domain
  • several polyproline stretches, proline-rich sequences critical for binding to c-Abl
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Abi2 (98.9 pc)
    homolog to murine Abi2 (99.3 pc)
    Homologene
    FAMILY
  • ABI family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text localized in lamellipodia and filopodia (Stradal 2001)
    basic FUNCTION
  • may be functioning as a tumor suppressor (Dai 1995)
  • may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2 (Dai 1995)
  • may be involved in cytoskeletal reorganization (Stradal 2001)
  • involved in actin polymerization or depolymerization
  • regulating ABL1/c-Abl-mediated phosphorylation of EGFR (Hirao 2006)
  • being a SH3/SH2 adaptor
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ABL1 and ABL2 (Dai 1995)
  • binding to TRIM32 (Kano 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS