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FLASH GENE
Symbol ROR2 contributors: shn/ - updated : 24-06-2018
HGNC name receptor tyrosine kinase-like orphan receptor 2
HGNC id 10257
ANIMAL & CELL MODELS
  • Disruption of mouse Ror2 leads to profound skeletal abnormalities with essentially all endochondrally derived bones foreshortened or misshapen
  • Ror2-deficient mice had cardiac septal defects and skeletal abnormalities, including shorter limbs, vertebrae, and facial structure, with a particular defect in their distal portions and died after birth
  • Ror1/Ror2 double-mutant mice showed skeletal abnormalities including a sternal defect and dysplasia of the symphysis of the pubic bone