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Symbol DMRT1 contributors: mct - updated : 01-10-2019
HGNC name doublesex and mab-3 related transcription factor 1
HGNC id 2934
  • loss of Dmrt1 in 129Sv mice results in a high incidence of teratomas and Dmrt1 acts as a dose-sensitive tumor suppressor gene that directly controls transcription of the pluripotency regulator Sox2 in germ cells
  • XY Dmrt1-null mutant mice are born as males with testes, although these gonads later undergo abnormal differentiation
  • Lack of Dmrt1 in the fetal ovary results in the formation of many fewer primordial follicles in the juvenile ovary, although these are sufficient for fertility