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FLASH GENE
Symbol UNC119 contributors: mct/shn - updated : 31-08-2017
HGNC name unc-119 homolog (C. elegans)
HGNC id 12565
ANIMAL & CELL MODELS
  • transgenic mice carrying a premature termination codon mutation developed age-dependent fundus lesions with electroretinographic changes consistent with defects in photoreceptor synaptic transmission , and retinal degeneration (
  • reduction in proteins associated with synaptic vesicles and a possible compensatory increase in proteins involved in docking-exocytosis and endocytosis were observed in both the outer and inner plexiform layers of the retina of the transgenic HRG4 mouse model (
  • deletion of UNC119 gene in both mouse and C. elegans led to G protein mislocalization (