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HGNC UniGene Nucleotide OMIM UCSC
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FLASH GENE
Symbol MSTN contributors: mct/pgu - updated : 18-01-2015
HGNC name myostatin
HGNC id 4223
ANIMAL & CELL MODELS
  • myostatin knockout in mice increases myogenesis and decreases adipogenesis
  • Mstn(-/-) mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity
  • Mstn-deficient animals result in an increase of skeletal muscle mass with both hyperplasia and hypertrophy
  • Mstn-null mice exhibited delayed skin wound healing attributable to a combination of effects resulting from delayed epidermal reepithelialization and dermal contraction