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FLASH GENE
Symbol CFTR contributors: mct/ - updated : 13-01-2016
HGNC name cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
HGNC id 1884
ANIMAL & CELL MODELS
  • mice lacking functional CFTR (Cftrdelta508) have no lung phenotype but show similar ileal problems to humans, but properties of the ileal mucus of CF mice were normalized by secretion into a high concentration sodium bicarbonate buffer
  • severe osteopenia and altered bone architecture were found in young and mature adult F508del Cftr(tm1Eur) mice