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| Nfia and Nfix null mice exhibit no apparent pontine phenotype, implying specificity in the action of NFI family members  | |
Nfib-deficient mice possess unique defects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but more severe than, those seen in Nfia-deficient animals |
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Nfib knockout embryos display multiple defects, including agenesis of the corpus callosum, enlarged ventricles, and hippocampal anomalies |
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Nfib(-/-) mice exhibit an increased number of proliferative ventricular zone cells that express progenitor cell markers and upregulation of Ezh2 expression within the neocortex and hippocampus |