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Symbol PTK2 contributors: shn/npt/pgu - updated : 14-02-2017
HGNC name PTK2 protein tyrosine kinase 2
HGNC id 9611
  • FAK-deficient mice display a general defect of mesoderm development, and cells from these embryos have reduced mobility in vitro
  • Null mutation of FAK results in embryonic lethality, and FAK-/- fibroblasts exhibit cell migration defects in culture
  • keratinocyte cell death was observed after fak deletion in vitro and in vivo in mice
  • mice in which FAK is selectively inactivated in cardiomyocytes develop eccentric cardiac hypertrophy ncreased heart/body weight ratios, elevated markers of cardiac hypertrophy, multifocal interstitial fibrosis, and increased collagen I and VI expression
  • focal adhesion kinase (FAK) conditional knockout mice display Cardiac developmental defects and eccentric right ventricular hypertrophy