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Symbol BDNF contributors: mct/pgu/shn - updated : 14-07-2016
HGNC name brain-derived neurotrophic factor
HGNC id 1033
  • maturation of GABAergic innervation and inhibition was accelerated in mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated and they showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity
  • early postnatal lethality of BDNF null mice
  • heterozygous BDNF(+/-) mice develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood
  • transgenic overexpression of BDNF in mouse has a facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala and antidepressant effects
  • BDNF(Val66Met/Val66Met) mice exhibited increased anxiety-related behaviors in stressful settings