Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
Symbol PKD2 contributors: mct/shn/pgu - updated : 19-01-2021
HGNC name polycystic kidney disease 2 (autosomal dominant)
HGNC id 9009
  • Pkd2-/- mice die in utero between embryonic day (E) 13.5 and parturition with structural defects in cardiac septation and cyst formation in maturing nephrons and pancreatic ducts. Pkd2WS25/- mice have pancreatic ductal and kidney cysts associated with renal failure and early death
  • Pkd2 (+/-) and Pkd1(+/-) : Pkd2 (+/-) mice have mild renal cystic lesions with no adverse effect on survival at 1 year
  • Pkd2 (+/-) mice develop hypertension, intracranial vascular abnormalities and vascular smooth muscle cells and have significantly altered intracellular Ca(2+) homeostasis