|
| Mice homozygous for mutant allele p(100H), which interrupt the p gene and the Sox6 gene, show delayed growth, develop progressive atrioventricular heart block, significant ultrastructural changes in both cardiac, skeletal muscle cells and die within 2 wk after birth  | |
Sox6 single null mice are born with mild skeletal abnormalities |
|
Sox5-Sox6 double null fetuses die with a severe, generalized chondrodysplasia |
|
Sox6-deficient mice are anemic due to impaired red cell maturation and show inappropriate globin gene expression in definitive erythrocytes |