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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ADAM23

contributors: npt/mct - updated : 16-11-2022

HGNC name	ADAM metallopeptidase domain 23
HGNC id	202

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   silenced in gastric cancer by homozygous deletion or aberrant promoter hypermethylation tumoral     --low   by aberrant promoter hypermethylation during the progression of colorectal cancer tumoral     --low   low expression levels of LGI3, ADAM22 and ADAM23 were significantly associated with poor prognosis of glioma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     regulation of ADAM23 endocytosis/stability could be exploited therapeutically in diseases in which ADAM23 is directly involved, such as cancer progression neurology epilepsy   regulation of ADAM23 endocytosis/stability could be exploited therapeutically in diseases in which ADAM23 is directly involved, such as epilepsy cardiovascular aquired heart failure regulation of ADAM23 endocytosis/stability could be exploited therapeutically in diseases in which ADAM23 is directly involved, such as cardiac hypertrophy

ANIMAL & CELL MODELS