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FLASH GENE
Symbol ANGPTL3 contributors: mct/npt/pgu - updated : 06-06-2016
HGNC name angiopoietin-like 3
HGNC id 491
ASSOCIATED DISORDERS
corresponding disease(s) FHBL2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
significantly increased podocyte motility, and dramatically increased the expression of nephrin
tumoral     --over  
in esophageal cancer tissues
constitutional       loss of function
does not affect the number of APOB-containing lipoproteins secreted by the liver but alters the particles that are made such that they are cleared more rapidly from the circulation via a noncanonical pathway(s)
constitutional     --over  
in glomerular podocytes of nephrotic syndrome
constitutional       loss of function
results in very low levels of LDL-cholesterol (C), HDL-C and triglyceride (TAG)
Susceptibility atherosclerosis, coronary artery disease, diabetes mellitus
Variant & Polymorphism
Candidate gene
Marker
  • association of ANGPTL3 expression with the prognosis of subgroups of patients with esophageal cancer
  • Therapy target
    SystemTypeDisorderPubmed
    metabolismlipidcholesterol
    therapeutic antibodies that neutralize ANGPTL4 and ANGPTL3 may be useful for treatment of some forms of hyperlipidemia
    metabolismlipid 
    potential therapeutic target to treat combined hyperlipidemia, a major risk factor for atherosclerotic coronary heart disease
    ANIMAL & CELL MODELS
    KK obese mouse