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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

CD59

contributors: mct - updated : 31-10-2012

HGNC name	CD59 molecule, complement regulatory protein
HGNC id	1689

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CD59D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in cardiac hypertrophy constitutional     --low   on peripheral blood leucocytes in T2DM patients with macrovascular diseases

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast may be a promising target in the gene therapy of breast cancer cancer     blockade of CD59 significantly enhanced the CD4(+) T cell response to two different tumor Ags

ANIMAL & CELL MODELS

	Cd59a inhibits systemic autoimmunity in MRL/lpr mice through a complement-independent mechanism
	Cd59 protects against angiotensin II-induced abdominal aortic aneurysms in mice
	number of endoneurial macrophages was significantly higher in Cd59a deficient mice compared to wildtypes at 1 day post-injury