Symbol
| HSPB1
| contributors: mct/pgu - updated : 09-05-2016
|
HGNC name
| heat shock 27kDa protein 1
|
HGNC id
| 5246
|
corresponding disease(s)
|
CMT2F
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in gastric cancer | constitutional
|  
|  
| --low
|  
|
in atherosclerotic plaques | constitutional
|  
|  
| --over
|  
|
in acute coronary syndrome | tumoral
|  
|  
| --over
|  
|
is increased in chroni pancreatitis and pancreatic carcinoma  | tumoral
|  
|  
| --over
|  
|
in angiogenic human breast cancer cells compared with nonangiogenic human breast cancer cells  | tumoral
|  
|  
| --low
|  
|
aberrant promoter hypermethylation of the HSPB1 gene may explain the reduced expression of HSPB1 noted in oral cancer cells  | |
Susceptibility
|
lower lymphocyte HSPB1 levels might be associated with an increased risk of lung cancer  |
Variant & Polymorphism
|
| |
Candidate gene
| defects in these gene are cause of distal hereditary motor neuropathy  |
|
expression of HSPB1 is an accurate and independent predictive biomarker of aggressive disease with a poor clinical outcome in prostate cancer without ETS-gene rearrangement  |
|
potentail novel serum marker for the diagnosis of chronic obstructive pulmonary disease in the smoking population  |
|
altered expression of this protein in testes showing abnormal spermatogenesis may be related to the pathogenesis of male infertility  |
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | |  |
targeting HSPB1 might offer a useful strategy in cancer treatment | neurology | neurodegenerative | |  |
. PEP1-HSPB1 fusion protein may be a potential therapeutic agent for familial amyotrophic lateral sclerosis patients | cancer | digestive | colon |  |
may be a clinical target in patients with 5-FU-resistant colon cancer | cancer | | |  |
target for interrupting signaling from membrane sex steroid receptors to tumor biology in hormone-responsive cancers |
| | |
| HspB1-deficient murine fibroblasts exhibit reduced entry into S phase and increased expression of cyclin-dependent kinase inhibitors p27(kip1) and p21(waf1) |