| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
|
in prostate cancer |
| tumoral
|
|
| --low
|
|
|
by promoter hypermethylation-mediated in astrocytoma |
| tumoral
|
|
|
| loss of function
|
is one of the key mechanisms for constitutive activation of YAP1, which induces deregulation of malignant mesothelioma cell proliferation  |
| tumoral
|
|
| --low
|
|
|
of LATS1 and LATS2 by promoter hypermethylation is associated with a biologically aggressive phenotype in breast cancer |
| tumoral
|
|
| --low
|
|
|
in breast and prostate cancer and acts as an important tumor suppressor relay between the FOXP3 and HIPPO pathways which are widely implicated in cancer ( |
| constitutional
|
|
| --over
|
|
|
reduced left ventricular systolic and diastolic function without affecting baseline levels of myocardial apoptosis |
