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FLASH GENE

Symbol

SIX2

contributors: mct - updated : 13-10-2015

HGNC name	SIX homeobox 2
HGNC id	10888

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function is a potential congenital cause of anterior cranial base defects in humans constitutional       loss of function of SIX2 and BMP4, could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with renal hypodysplasia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Six2-null newborn mice display premature fusion of the bones in the cranial base