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FLASH GENE
Symbol WASF2 contributors: mct/ - updated : 09-09-2016
HGNC name WAS protein family, member 2
HGNC id 12733
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   LOH    
the chromosome region frequently undergoes loss of heterozygosity in advanced stage of neuroblastoma
tumoral   deletion    
the chromosome region frequently undergoes deletion in advanced stage of neuroblastoma
tumoral     --over  
in node-positive cases as well as in moderately and poorly differentiated breast tumours
constitutional     --low  
excessive oxidative stress can decrease WASF2 expression in trophoblasts and the decreased expression of WASF2 in trophoblast cells may be involved in the development of pre-eclampsia
Susceptibility
Variant & Polymorphism
Candidate gene for a candidate prognostic marker of hepatocellular carcinoma (HCC)
Marker
Therapy target
ANIMAL & CELL MODELS
  • Wave2 deficient mice generated by a targeted gene disruption