Symbol
| WASF2
| contributors: mct/ - updated : 09-09-2016
|
HGNC name
| WAS protein family, member 2
|
HGNC id
| 12733
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
| LOH
|  
|  
|
the chromosome region frequently undergoes loss of heterozygosity in advanced stage of neuroblastoma | tumoral
|  
| deletion
|  
|  
|
the chromosome region frequently undergoes deletion in advanced stage of neuroblastoma | tumoral
|  
|  
| --over
|  
|
in node-positive cases as well as in moderately and poorly differentiated breast tumours | constitutional
|  
|  
| --low
|  
|
excessive oxidative stress can decrease WASF2 expression in trophoblasts and the decreased expression of WASF2 in trophoblast cells may be involved in the development of pre-eclampsia | |
Variant & Polymorphism
|
| |
Candidate gene
| for a candidate prognostic marker of hepatocellular carcinoma (HCC) |
Marker
Therapy target
| | |
| Wave2 deficient mice generated by a targeted gene disruption |