Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RORB contributors: mct - updated : 09-05-2013
HGNC name RAR-related orphan receptor B
HGNC id 10259
ASSOCIATED DISORDERS
corresponding disease(s) DEL9Q21
Susceptibility to pediatric bipolar disorder
Variant & Polymorphism SNP
  • four intronic RORB SNPs showed positive associations with the pediatric bipolar disorder
  • Candidate gene RORB is a strong candidate for a neurological phenotype in del 9q21 patients
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rorb(-/-) mice lacking retinoid-related orphan nuclear receptor beta lose rods but overproduce primitive S cones that lack outer segments
  • Rorbeta-deficient mice fail to induce S opsin appropriately during postnatal cone development
  • Rorb-deficient mice lose expression of pancreas-specific transcription factor 1a (Ptf1a) but retain forkhead box n4 factor (Foxn4), two early-acting factors necessary for amacrine and horizontal cell generation 1