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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CD9

contributors: mct/shn - updated : 04-09-2017

HGNC name	CD9 molecule
HGNC id	1709

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in endometrioid adenocarcinoma and in squamous cell carcinoma of the head and neck with high grade and poor prognosis tumoral     --low   associated with the negative progression and metastasis outbreak of multiple cancer type, including prostate, breast, colon, non-small cell lung cancer, oral squamous cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual   inhibition of CD9 expression or function via intravitreous injections of siRNA-CD9 or anti-CD9 antibodies may provide a new therapeutic strategy for angiogenesis such as that observed in certain ocular diseases

ANIMAL & CELL MODELS

	CD9-/- mouse females displayed a severe reduction of fertility
	litter size from CD9-/- mouse was less than 2% of that of the wild type
	CD9 homozygous mutant mouse females were infertile