Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MALT1 contributors: mct - updated : 16-01-2015
HGNC name mucosa associated lymphoid tissue lymphoma translocation gene 1
HGNC id 6819
ASSOCIATED DISORDERS
corresponding disease(s) MALTLY , IMD12
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
rearranged with API2 in the t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphomas, in low-grade B cell lymphoma of mucosa associated lymphoid tissue
tumoral fusion      
of exon 9 of MALT1 and exon 9 of MAP4 in diffuse large B-cell lymphoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
development of selective MALT1 inhibitors as a rational strategy for the therapy of NF-kB-dependent type of cancer (diffuse large B-cell lymphoma DLBCL)
cancerhemopathy 
targeting MALT1 proteolytic activity raises the possibility of deploying MALT1 inhibitors for the treatment of B-cell lymphomas and perhaps autoimmune diseases that involve increased B- or T-cell receptor signaling
cancerhemopathy 
monoubiquitination of MALT1 is essential for its catalytic activation and is therefore a potential target for the treatment of ABC-DLBCL and for immunomodulation
ANIMAL & CELL MODELS