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FLASH GENE
Symbol ZMPSTE24 contributors: mct/npt - updated : 26-10-2016
HGNC name zinc metallopeptidase (STE24 homolog, S. cerevisiae)
HGNC id 12877
ASSOCIATED DISORDERS
corresponding disease(s) MADYS2 , RDMP1 , LPCMD , HGPSA
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
  • ANIMAL & CELL MODELS
  • Zmpste24-null progeroid mice (Zmpste24(-/-)), exhibit nuclear lamina defects and accumulate unprocessed prelamin A (Rivas 2009)
  • zmpste24&
  • 8722;/&
    8722; mouse exhibits a severe progeroid disorder that is completely alleviated in a mouse heterozygous for lamin A (zmpste24/ lmna+/), which reduces the load of toxic prelamin A by 50p100