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FLASH GENE

Symbol

ZMPSTE24

contributors: mct/npt - updated : 26-10-2016

HGNC name	zinc metallopeptidase (STE24 homolog, S. cerevisiae)
HGNC id	12877

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MADYS2 , RDMP1 , LPCMD , HGPSA

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target

ANIMAL & CELL MODELS

	Zmpste24-null progeroid mice (Zmpste24(-/-)), exhibit nuclear lamina defects and accumulate unprocessed prelamin A (Rivas 2009)
	zmpste24&
	8722;/&
	8722; mouse exhibits a severe progeroid disorder that is completely alleviated in a mouse heterozygous for lamin A (zmpste24–/– lmna+/–), which reduces the load of toxic prelamin A by 50p100