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FLASH GENE

Symbol

TRPC6

contributors: mct/shn/pgu - updated : 22-05-2024

HGNC name	transient receptor potential cation channel, subfamily C, member 6
HGNC id	12338

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FSGS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   upregulated in gastric cancer epithelial cells constitutional       gain of function is involved in Ca(2+) signaling and actin reorganization in podocytes after oxygen glucose deprivation (OGD)

Susceptibility

to idiopathic membranous glomerulopathy (iMN)

Variant & Polymorphism SNP	a SNP in the promoter region and a missense variant in exon 4 may be putative causal variants for infantile hypertrophic pyloric stenosis
	254C->G SNP may predispose individuals to an increased risk of idiopathic pulmonary arterial hypertension
	genetic variants in TRPC6 might affect susceptibility to development or progression of iMN

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     newly-identified ROS/TRPC6 pathway will pave the way to new, promising therapeutic strategies to target kidney diseases such as diabetic nephropathy respiratory lung   manipulation of TRPC6 function may thus offer a therapeutic strategy for the control of pulmonary hemodynamics and gas exchange dermatology skin   activation by hyperforin may represent a new innovative therapeutic strategy in skin disorders characterized by altered keratinocyte differentiation cancer brain   key mediator of tumor growth of glioblastoma multiforme (GBM) and may be a promising therapeutic target in the treatment of GBM cardiovascular aquired heart failure . pharmacologic inhibitors of TRPC channels might be a strategy for attenuating local Ca2+ signals involved in pathologic cardiac hypertrophy or failure miscelleaneous hypertension   TRPC6 channel is a good target for developing novel treatment for pulmonary arterial hypertension (PAH), and BI-749327, a selective TRPC6 blocker, is potentially a novel and effective drug for treating PAH immunology infectious   TRPC6 might aggravate SARS COV-2 induced inflammation and could be a target for inhibiting drugs

ANIMAL & CELL MODELS

in TRPC6-/- mice, a higher contractility in isolated tracheal and aortic rings was observed following application of the agonists methacholine and phenylephrine, respectively, as well as a reduced agonist-induced expiration rate (