Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AXIN1 contributors: mct/pgu - updated : 28-08-2016
HGNC name axin 1
HGNC id 903
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral somatic mutation      
in hepatocellular (late event for malignant progression), colorectal, ovarian carcinoma, hepatoblastoma and medulloblastoma
tumoral     --low  
hypermethylated AXIN1 gene significantly correlates with the progression of lung cancer
Susceptibility
Variant & Polymorphism
Candidate gene candidate in multiple tumor types; for caudal duplication (murine model)
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
AXIN1 may be a potential target for gene therapy of primary hepatocellular carcinoma (HCC) (PMID: 23879168)
ANIMAL & CELL MODELS
AxinFu mice