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FLASH GENE

Symbol

KDM6B

contributors: mct/npt/pgu - updated : 08-02-2022

HGNC name	lysine (K)-specific demethylase 6B
HGNC id	29012

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NEDCFSA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis tumoral     --low   in poorly differentiated high-risk neuroblastomas tumoral     --over   in differentiated tumors, and high KDM6B expression is prognostic for better survival in neuroblastoma patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	low KDM6B was an independent predictor of poor prognosis in surgically resected colorectal cancer (CRC) patients
Therapy target
	System Type Disorder Pubmed immunology autoimmune   KDM6B can be a novel therapeutic target for suppressing autoimmune responses osteoarticular bone ostéoporosis KDM6B may present as therapeutic targets for controlling mesenchymal stem/stromal cells (MSCs) fate choices and lead to clues for new treatment in metabolic bone diseases such as osteoporosis cardiovascular atheroma   cell-specific pharmacologic therapy targeting KDM6B may be an effective intervention for Abdominal aortic aneurysms (AAAs) expansion cancer digestive colon potential new therapeutic targetapproach for CRC patients

ANIMAL & CELL MODELS

Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis (EAE)