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Symbol NR4A2 contributors: mct - updated : 16-01-2015
HGNC name nuclear receptor subfamily 4, group A, member 2
HGNC id 7981
corresponding disease(s) PARK26
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
in familial Parkinson disease
constitutional     --over  
in cartilage derived from patients with osteoarthritis
constitutional     --over  
in the T cells isolated from the CNS of multiple sclerosis
constitutional     --low  
in end-stage dilated cardiomyopathy
constitutional     --low  
in patients with Parkinson disease
  • to attention deficit hyperactivity disorder (ADHD)
  • to Parkinson disease
  • to autism spectrum disorder (ASD)
  • Variant & Polymorphism other
  • polymorphisms associated to attention deficit hyperactivity disorder (ADHD)
  • copy-number variants (CNVs) in NR4A2 contribute significantly to autism spectrum disorder (ASD) risk
  • Candidate gene
    Therapy target
  • molecular target for blocking inflammation and tissue destruction associated with chronic inflammatory diseases
  • essential transcription factor for triggering the inflammatory cascade of multiple sclerosis and may serve as a therapeutic target
  • expression increased in diabetic mice that exhibit elevated gluconeogenesis
  • Nurr1 ablation in mice recapitulates early features of Parkinson disease