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FLASH GENE

Symbol

KMT2D

contributors: mct/npt - updated : 28-04-2015

HGNC name	lysine (K)-specific methyltransferase 2B
HGNC id	7133

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

KABUK1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mice lacking mll2/kmt2b gene in adult forebrain excitatory neurons display impaired hippocampus-dependent memory function
	mice heterozygous for two separate mutations in the SET domain of Mll2 or heterozygous Mll2 knockout mice were hyperglycaemic, hyperinsulinaemic and developed non-alcoholic fatty liver disease (PMIX: 23826075)