Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CCL21

contributors: mct/npt - updated : 11-02-2017

HGNC name	chemokine (C-C motif) ligand 21
HGNC id	10620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in hepatitis C, to modulating lymphocyte recruitment and fibrosis constitutional     --over   specifically in hyperplastic Myasthenia gravis thymuses tumoral     --low   in colorectal adenocarcinomas

Susceptibility

to inflammatory polyarthritis (IP)

Variant & Polymorphism other	CCL21 risk alleles was associated with premature mortality in IP

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous urinary chronic kidney disease CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis miscelleaneous pain   target to a preventive therapy in neuropathic pain

ANIMAL & CELL MODELS

mice deficient for CCL21 did not develop any signs of tactile allodynia and failed to up-regulate microglial P2X4 receptor expression