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FLASH GENE
Symbol P2RY6 contributors: mct - updated : 08-02-2013
HGNC name pyrimidinergic receptor P2Y, G-protein coupled, 6
HGNC id 8543
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
immunologyinflammatory 
therapeutic target during systemic inflammatory responses
ANIMAL & CELL MODELS
  • P2Y(6)R(-/-) mice have increased bone mineral content, cortical bone volume, and cortical thickness in the long bones and spine, whereas trabecular bone parameters were unaffected
  • P2ry6-deficient mice and have shown that these mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cell