Symbol
| P2RY6
| contributors: mct - updated : 08-02-2013
|
HGNC name
| pyrimidinergic receptor P2Y, G-protein coupled, 6
|
HGNC id
| 8543
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
|  
|  
| --over
|  
|
when neurons are damaged, and could function as a sensor for phagocytosis by sensing diffusible UDP signals | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
immunology | inflammatory | | |
therapeutic target during systemic inflammatory responses |
| | | |
| P2Y(6)R(-/-) mice have increased bone mineral content, cortical bone volume, and cortical thickness in the long bones and spine, whereas trabecular bone parameters were unaffected | |
P2ry6-deficient mice and have shown that these mice have a defective response to UDP in macrophages, endothelial cells, and vascular smooth muscle cell |