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FLASH GENE

Symbol

DUSP6

contributors: mct - updated : 27-10-2011

HGNC name	dual specificity phosphatase 6
HGNC id	3072

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in primary pancreatic cancer tumoral     --over   exerts a tumor-promoting role in human glioblastomas exacerbating the malignant phenotype constitutional     --over   in optic nerves from multiple sclerosis patients before the appearance of evident damage in this structure

Susceptibility

to congenital Hypogonadotropic Hypogonadism

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune multiple sclerosis targeting Dusp6 may be a useful strategy to prevent oligodendrocyte death in multiple sclerosis and other diseases involving CNS white matter.

ANIMAL & CELL MODELS