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FLASH GENE

Symbol

FGF14

contributors: mct - updated : 15-03-2023

HGNC name	fibroblast growth factor 14
HGNC id	3671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCABG , ATCAD2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of SCN8A channels tumoral     --low   by hypermethylation in colorectal cancer (CRC) tumoral     --over   associated with better overall survival (OS) in pancreatic cancer constitutional     --low   in Downbeat nystagmus (DBN)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

inactivation of Fgf14 in mice results in markedly reduced Purkinje neuron excitability