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FLASH GENE

Symbol

GRB10

contributors: mct/pgu - updated : 13-10-2013

HGNC name	growth factor receptor-bound protein 10
HGNC id	4564

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SRS7

Susceptibility

Variant & Polymorphism

Candidate gene	candidate for growth disturbance disorders
Marker
Therapy target

ANIMAL & CELL MODELS

	adult mice deficient in Grb10 have elevated body mass and muscle mass throughout adulthood, up to 12 mo of age, and grb10 plays a previously unrecognized role in regulating the development of fiber number during murine embryonic growth
	Grb10(-/-) mice exhibit improved whole body glucose homeostasis and an increase in muscle mass associated specifically with an increase in myofiber number