| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| gain of function
| |
in breast carcinoma, gastric and lung cancer with metastasis | | tumoral
|
|
| --over
|
| |
in gliomas and promotes invasion | | tumoral
|
|
| --low
|
|
by hypermethylation is observed frequently in colorectal tumors  | | tumoral
|
|
| --over
|
| |
associated with unfavorable outcomes in patients with colorectal cancer | | tumoral
| somatic mutation
|
|
|
| |
in giant cell tumor of bone, leading to inappropriate TWIST1 downregulation of RUNX2, arrested osteoblastic differentiation, and the maintenance of an immature and neoplastic phenotype ( | | constitutional
|
|
| --other
|
| |
epithelial expression of TWIST1 were disturbed in those placentas with chromosomal aberrations | | constitutional
|
|
| --over
|
| |
hypomethylation is associated with overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome | |
