Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC6A8 contributors: mct/pgu - updated : 13-06-2018
HGNC name solute carrier family 6 (neurotransmitter transporter, creatine), member 8
HGNC id 11055
ASSOCIATED DISORDERS
corresponding disease(s) CRTRD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in astrocytes around the blood-brain barrier limits the brain capacity to import creatine from the periphery, and suggests that the CNS has to rely mainly on endogenous creatine synthesis through GATM/GAMT
constitutional     --low  
depletion of intracellular creatine by ablation of the creatine transporter SLC6A8 altered macrophage-mediated immune responses
constitutional     --low  
in dopaminergic neurons causes hyperactivity while sparing motor function
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
potential of creatine supplementation to improve T cell-based cancer immunotherapies
cancerlung 
expected to become a molecular target for NSCLC treatment
ANIMAL & CELL MODELS