| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
| fusion
|
|
|
|
|
with FOP in t(6;8)(q27;p11),with CEP1 in t(8;9)(p11;q33), with ZNF198 in t(8;13)(p11;q12) |
| tumoral
| somatic mutation
|
|
|
|
|
aberrant alternative splicing in glioblastoma (exon skipping) |
| tumoral
| fusion
|
|
|
|
|
with BCR in t(8;22) (p11;q11) |
| tumoral
|
| amplification
|
|
|
during the progression of in situ to invasive breast carcinoma  |
| tumoral
|
|
|
| gain of function
|
|
in the 8p11 myeloproliferative syndrome |
| tumoral
| fusion
|
|
|
|
|
with TIF1 in t(7;8)(q34;p11)in myeloproliferative syndrome |
| tumoral
| fusion
|
|
|
|
|
with TNS3 in t(7;8) (p12.3;p11.2)in Kallmann syndrome with cleft lip and cleft palate |
| tumoral
| fusion
|
|
|
|
|
to CPSF6, in t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome |
| constitutional
|
|
| --other
|
|
|
dysfunction (expression) of the FGFR1, SOS1 and RAF1 genes is involved in the development of unilateral or bilateral cryptorchidism |
| tumoral
|
|
| --over
|
|
|
in renal cell carcinoma |
| tumoral
| fusion
|
|
|
|
|
NTRK2 is a new gene fusion target in pilocytic astrocytoma (fusion with QKI, FGFR1) |
| tumoral
| fusion
|
|
|
|
|
to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively in glioblastoma |
| tumoral
| fusion
|
|
|
|
|
fusion FGFR1/TPR in 8p11 myeloproliferative syndrome |
| tumoral
| fusion
|
|
|
|
|
ZMYM2-FGFR1 fusion in myeloproliferative syndrome |
| tumoral
|
| amplification
|
|
|
|
in squamous lung carcinomas |
