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FLASH GENE
Symbol TYRP1 contributors: mct/npt - updated : 07-10-2017
HGNC name tyrosinase-related protein 1
HGNC id 12450
ASSOCIATED DISORDERS
corresponding disease(s) OCA3
related resource Albinism Database
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
melanocytes in vitiligo have reduced ability to withstand oxidative stress due, partly, to a disruption in MITF regulation of TYRP1
Susceptibility to cutaneous melanoma (CM)
Variant & Polymorphism other haplotype increasing the risk of cutaneous melanoma (CM)
Candidate gene
Marker
  • prognostic marker for melanoma, and is particularly useful when prognostic pathology parameters at the primary lesion are lacking
  • Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    its conserved expression further supports TYRP1 use as a target for therapy
    cancereye 
    potential use of TYRP1 in the development of therapy for Uveal melanoma (UM)
    ANIMAL & CELL MODELS