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FLASH GENE

Symbol

IL6

contributors: mct - updated : 03-12-2018

HGNC name	interleukin 6 (interferon, beta 2)
HGNC id	6018

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in inflammatory bowel diseases tumoral     --over   in inflammatory breast cancer constitutional     --over   in midlife predicts cognitive decline constitutional     --over   in primary and secondary models of lymphedema constitutional     --over   increased in the plasma of patients with cerebral arteriovenous malformation constitutional     --over   in hepatitis B patients

Susceptibility

susceptibility in carotid artery atherosclerosis and osteopenia to Kaposi sarcoma to juvenile rheumatoid arthritis (OMIM: 604302) to cerebral palsy in term and near-term infants (CP) to type 2 diabetes to osteoporosis (bone mineral density) elevated IL-6 levels are strongly associated with future cardiac events and mortality in a population with stable coronary artery disease during a long-term follow-up to sporadic Alzheimer's disease

Variant & Polymorphism other	in juvenile rheumatoid arthritis
	G/C promoter polymorphism in NIDDM (in native Americans and Caucasians)
	C174G associated with bone loss in postmenopausal women
	-572C/G polymorphism of IL6 gene promoter region is associated with AD, and G allele is an independent protective factor for AD
	functional polymorphism in the IL6 gene is a risk factor for CP among term and near-term infants

Candidate gene
Marker	cerebrospinal fluid (CSF) IL6 may help to differentiate multiple sclerosis (MS) from other inflammatory neurological diseases (OIND)
Therapy target
	System Type Disorder Pubmed immunology autoimmune articular antibodies specific as therapeutic targets in rheumatoid arthritis immunology infectious aquired therapeutic neutralization of IL6 for treatment of certain diseases may represent a risk if the patient is HBV-infected diabete     use of therapeutic strategies aimed at antagonizing CCL2 or IL6 signaling in diabetic kidney injury immunology autoimmune articular potential therapeutic target in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA)

ANIMAL & CELL MODELS