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FLASH GENE

Symbol

DHFR

contributors: mct - updated : 18-03-2011

HGNC name	dihydrofolate reductase
HGNC id	2861

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DHFRD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     polymorphism in intron 1 significantly more frequent in mother with foetus spina bifida constitutional   deletion     associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate

Susceptibility

to spina bifida to intracranial aneurysms

Variant & Polymorphism other	polymorphisms are possible risk factors for the formation of intracranial aneurysms

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     critical target in cancer chemotherapy

ANIMAL & CELL MODELS