Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ACAT2

contributors: mct - updated : 31-08-2010

HGNC name	acetyl-Coenzyme A acetyltransferase 2
HGNC id	94

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

coronary artey disease risk and high plasma lipid levels

Variant & Polymorphism	polymorphisms associated with CAD risk and plasma lipid levels

Candidate gene
Marker
Therapy target	target for prevention and treatment of hypercholesterolemia and atherosclerosis
	ACAT2-specific inhibitors may hold unexpected therapeutic potential to treat both atherosclerosis and non-alcoholic fatty liver disease (Alger 2010)

ANIMAL & CELL MODELS

mice genetically lacking ACAT2 in both the intestine and the liver were dramatically protected against hepatic neutral lipid (TG and cholesteryl ester) accumulation, with the greatest differences occurring in situations where dietary cholesterol was elevated (Alger 2010)