Symbol
| PPP2CA
| contributors: mct/npt/pgu - updated : 29-01-2019
|
HGNC name
| protein phosphatase 2, catalytic subunit, alpha isozyme
|
HGNC id
| 9299
|
corresponding disease(s)
|
IDHE
|
Variant & Polymorphism
|
| |
Candidate gene
Marker
| prognostic marker in Colorectal cancer | Therapy target
|
System | Type | Disorder | Pubmed |
neurology | neurodegenerative | alzheimer | |
PPP2CA and its regulatory subunits may be a therapeutic target for Alzheimer's disease | cancer | digestive | colon | |
therapeutic target in Colorectal cancer | cancer | bone | | |
its inhibition could potentially suppress the malignancy of osteosarcoma cells | diabete | type 2 | | |
inhibition of hepatic PPP2CA may be a useful strategy for the treatment of insulin resistance syndrome |
| | |
| double-transgenic Dom5/pR5 mice showed 7-fold increased numbers of hippocampal neurons that specifically phosphorylated the pathological S422 epitope of tau |