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FLASH GENE
Symbol PCSK2 contributors: mct - updated : 26-08-2015
HGNC name proprotein convertase subtilisin/kexin type 2
HGNC id 8744
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
decreased hypothalamic PCSK1, PCSK2, FURIN in huntington disease patients
Susceptibility to type 2 diabetes
Variant & Polymorphism
  • variant of the PCSK2 gene associated with reduced glucose-stimulated insulin secretion, but also with lower glucagon levels, which could potentially counteract the effects of decreased insulin secretion on the risk of type 2 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pcsk2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides