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FLASH GENE
Symbol FGF2 contributors: mct/shn - updated : 08-02-2018
HGNC name fibroblast growth factor 2 (basic)
HGNC id 3676
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in ovarian, testicular, breast cancer
constitutional     --over  
overproduced in idiopathic pulmonary hypertension (IPH) and contributes to SMC hyperplasia in IPH
constitutional     --over  
in the AD brain
constitutional     --low  
FGF2 expression is decreased in HOXA10-deficient cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativehuntington chorea
potential therapy target in Huntington disease
neurologyneurodegenerative 
virus-mediated FGF2 gene delivery has potential as an alternative therapy of Alzheimer disease and possibly other neurocognitive disorders
ANIMAL & CELL MODELS
  • mice lacking FGF2 are viable and fertile but display abnormalities in the cytoarchitecture of the neocortex, most pronounced in the frontal motor-sensory area, and a significant reduction in neuronal density in most layers of the motor cortex (
  • FGF-2-deficient mice display cerebral cortex defects at birthectopic parvalbumin-positive neurons are present in the hippocampal commissure and neuronal deficiencies are observed in the cervical spinal cord, and are hypotensive (
  • markedly reduced platelike trabecular structures, lost of many connecting rods of trabecular bone are, and a profound decreased mineralization of bone marrow stromal cultures in the Fgf2(-/-) mice (
  • anabolic action of PTH on bone formation is impaired in Fgf2-/- mice compared to wild type
  • Fgf2(-/-) mice exhibited decreased thermal pain sensitivity in the hotplate-test