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FLASH GENE
Symbol PCK1 contributors: mct - updated : 15-05-2020
HGNC name phosphoenolpyruvate carboxykinase 1 (soluble)
HGNC id 8724
ASSOCIATED DISORDERS
corresponding disease(s) PCKDC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
lower in clinical hepatocellular carcinoma (HCC) tissues than that in normal tissues
Susceptibility
  • to type 2 diabetes mellitus
  • to late-onset Alzheimer's disease
  • Variant & Polymorphism SNP promoter SNP associated with type 2 diabetes mellitus
    Candidate gene
    Marker
  • PCK1 may serve as a candidate prognostic biomarker in clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    targeting the PCK1/LDHA pathway might be a new strategy to selectively inhibit tumor metabolism in in clear cell renal cell carcinoma
    cancerdigestivecolon
    DHODH and PCK1 are metabolic therapeutic targets in Colorectal metastatic progression
    ANIMAL & CELL MODELS