Symbol
| AFF1
| contributors: mct - updated : 17-06-2020
|
HGNC name
| AF4/FMR2 family, member 1
|
HGNC id
| 7135
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
| fusion
|  
|  
|  
|
fusion partner with MLL in a patient affected by acute lymphoblastic leukemia | |
Susceptibility
|
to systemic lupus eyrthematosus (SLE) |
Variant & Polymorphism
other
| association of a variant in AFF1 at 4q21 with SLE susceptibility systemic lupus eyrthematosus |
|
|
Candidate gene
Marker
Therapy target
| | | |
| point mutation in Aff1/Af4 causes a dominant form of cerebellar ataxia in mouse |