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Symbol GFAP contributors: mct/npt - updated : 11-03-2020
HGNC name glial fibrillary acidic protein
HGNC id 4235
corresponding disease(s) ALXD1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in patients with structural lesions resulting from mild traumatic brain injuries
constitutional     --over  
in Alzheimer disease and correlates with cognitive impairment
constitutional     --over  
in the cerebrospinal fluid of Alzheimer disease, dementia with Lewy bodies, and frontotemporal lobar degeneration
constitutional     --over  
in anterior cingulate cortical white matter in males with autism spectrum disorder
Variant & Polymorphism
Candidate gene
  • role of GFAP and UCHL1 as candidate biomarkers for pediatric traumatic brain injury (TBI)
  • Marker
  • marker for astrogliosis, and is a potential biomarker for multiple sclerosis (MS) progression and may have a role in clinical trials for assessing the impact of therapies on MS progression
  • increased serum GFAP, S100B, ENO2 are associated with acute CO poisoning, and these biomarkers can be useful in assessing the clinical status of patients with CO poisoning
  • autoantibodies against GFAP could serve as a predictive marker for the development of overt autoimmune diabetes
  • is a promising diagnostic biomarker for intracerebral hemorrhage (ICH) diagnosis in the early pre-hospital phase
  • Therapy target