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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

GFAP

contributors: mct/npt - updated : 11-03-2020

HGNC name	glial fibrillary acidic protein
HGNC id	4235

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ALXD1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with structural lesions resulting from mild traumatic brain injuries constitutional     --over   in Alzheimer disease and correlates with cognitive impairment constitutional     --over   in the cerebrospinal fluid of Alzheimer disease, dementia with Lewy bodies, and frontotemporal lobar degeneration constitutional     --over   in anterior cingulate cortical white matter in males with autism spectrum disorder

Susceptibility

Variant & Polymorphism

Candidate gene	role of GFAP and UCHL1 as candidate biomarkers for pediatric traumatic brain injury (TBI)
Marker	marker for astrogliosis, and is a potential biomarker for multiple sclerosis (MS) progression and may have a role in clinical trials for assessing the impact of therapies on MS progression
	increased serum GFAP, S100B, ENO2 are associated with acute CO poisoning, and these biomarkers can be useful in assessing the clinical status of patients with CO poisoning
	autoantibodies against GFAP could serve as a predictive marker for the development of overt autoimmune diabetes
	is a promising diagnostic biomarker for intracerebral hemorrhage (ICH) diagnosis in the early pre-hospital phase
Therapy target

ANIMAL & CELL MODELS