| 1 | GFAP, NRGN, S100B
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| NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries.
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| Çevik S, Özgenç MM, Güneyk A, Evran Ş, Akkaya E, Çalış F, Katar S, Soyalp C, Hanımoğlu H, Kaynar MY.
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| Clin Neurol Neurosurg 183:105380. doi: 10.1016/j.clineuro.2019.105380. Epub 2019 Jun 17.
2019
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| 2 | GFAP
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| The role of GFAP and vimentin in learning and memory.
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| Wilhelmsson U, Pozo-Rodrigalvarez A, Kalm M, de Pablo Y, Widestrand Ċ, Pekna M, Pekny M.
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| Biol Chem 400(9):1147-1156. doi: 10.1515/hsz-2019-0199.
2019
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| 3 | GFAP
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| Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment.
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| Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A; Consortium for Frontotemporal Lobar Degeneration German, Ludolph AC, Otto M.
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| J Alzheimers Dis 67(2):481-488. doi: 10.3233/JAD-180325.
2019
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| 4 | GFAP
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| Glial fibrillary acidic protein for the early diagnosis of intracerebral hemorrhage: Systematic review and meta-analysis of diagnostic test accuracy.
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| Perry LA, Lucarelli T, Penny-Dimri JC, McInnes MD, Mondello S, Bustamante A, Montaner J, Foerch C, Kwan P, Davis S, Yan B.
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| Int J Stroke 14(4):390-399. doi: 10.1177/1747493018806167. Epub 2018 Oct 10.
2019
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| 5 | ALXD1, GFAP
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| Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes.
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| Jones JR, Kong L, Hanna MG 4th, Hoffman B, Krencik R, Bradley R, Hagemann T, Choi J, Doers M, Dubovis M, Sherafat MA, Bhattacharyya A, Kendziorski C, Audhya A, Messing A, Zhang SC.
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| Cell Rep 25(4):947-958.e4. doi: 10.1016/j.celrep.2018.09.083.
2018
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| 6 | GFAP, OSMR, SMARCA4, STAT3
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| Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes.
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| Ito K, Noguchi A, Uosaki Y, Taga T, Arakawa H, Takizawa T.
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| Mol Biol Cell 29(2):209-219. doi: 10.1091/mbc.E17-05-0271. Epub 2017 Nov 15.
2018
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| 7 | ALXD1, GFAP
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| Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.
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| Lee SH, Nam TS, Kim KH, Kim JH, Yoon W, Heo SH, Kim MJ, Shin BA, Perng MD, Choy HE, Jo J, Kim MK, Choi SY.
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| BMC Neurol 17(1):175. doi: 10.1186/s12883-017-0938-7.
2017
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| 8 | GFAP, LMNB1
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| Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis.
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| Mahajani S, Giacomini C, Marinaro F, De Pietri Tonelli D, Contestabile A, Gasparini L.
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| Sci Rep 7(1):4897. doi: 10.1038/s41598-017-05078-6.
2017
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| 9 | GFAP
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| Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.
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| Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.
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| FASEB J 31(9):4053-4063. doi: 10.1096/fj.201700110R. Epub 2017 May 25.
2017
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| 10 | GFAP, UCHL1
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| Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
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| Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP.
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| Sci Rep 6:28203. doi: 10.1038/srep28203.
2016
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| 11 | GFAP
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| GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.
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| Moeton M, Stassen OM, Sluijs JA, van der Meer VW, Kluivers LJ, van Hoorn H, Schmidt T, Reits EA, van Strien ME, Hol EM.
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| Cell Mol Life Sci 73(21):4101-20. doi: 10.1007/s00018-016-2239-5. Epub 2016 May 3.
2016
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| 12 | GFAP, PINK1
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| PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes.
|
| Choi I, Choi DJ, Yang H, Woo JH, Chang MY, Kim JY, Sun W, Park SM, Jou I, Lee SH, Joe EH.
|
| Mol Brain 9:5. doi: 10.1186/s13041-016-0186-6. Erratum in: Mol Brain. 2016;9:18. Lee, Sang Hoon [Corrected to Lee, Sang-Hun].
2016
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| 13 | GFAP
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| Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration.
|
| Ishiki A, Kamada M, Kawamura Y, Terao C, Shimoda F, Tomita N, Arai H, Furukawa K.
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| J Neurochem 136(2):258-61. doi: 10.1111/jnc.13399. Epub 2015 Nov 11.
2016
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| 14 | GFAP
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| Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.
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| Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT.
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| FASEB J 29(12):4815-28. doi: 10.1096/fj.15-272963. Epub 2015 Aug 6.
2015
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| 15 | GFAP
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| Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder.
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| Crawford JD, Chandley MJ, Szebeni K, Szebeni A, Waters B, Ordway GA.
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| Autism Res 8(6):649-57. doi: 10.1002/aur.1480. Epub 2015 Apr 6.
2015
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| 16 | ALXD1, GFAP
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| Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease.
|
| Nam TS, Kim JH, Chang CH, Yoon W, Jung YS, Kang SY, Shin BA, Perng MD, Choi SY, Kim MK.
|
| Eur J Hum Genet 23(1):72-8. doi: 10.1038/ejhg.2014.68. Epub 2014 Apr 23.
2015
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| 17 | GFAP
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| Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network.
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| Kanski R, Sneeboer MA, van Bodegraven EJ, Sluijs JA, Kropff W, Vermunt MW, Creyghton MP, De Filippis L, Vescovi A, Aronica E, van Tijn P, van Strien ME, Hol EM.
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| J Cell Sci 127(Pt 20):4368-80. doi: 10.1242/jcs.145912. Epub 2014 Aug 15.
2014
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| 18 | ENO2, GFAP, S100B
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| The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning.
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| Akdemir HU, Yardan T, Kati C, Duran L, Alacam H, Yavuz Y, Okuyucu A.
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| Hum Exp Toxicol 33(11):1113-20. doi: 10.1177/0960327114521049. Epub 2014 Feb 6.
2014
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| 19 | GFAP
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| Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation.
|
| Chen MH, Hagemann TL, Quinlan RA, Messing A, Perng MD.
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| ASN Neuro 5(5):e00125. doi: 10.1042/AN20130032.
2013
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| 20 | GFAP
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| Alternative mRNA splicing from the glial fibrillary acidic protein (GFAP) gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes.
|
| Thomsen R, Daugaard TF, Holm IE, Nielsen AL.
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| PLoS One 8(8):e72110. doi: 10.1371/journal.pone.0072110. eCollection 2013.
2013
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| 21 | ALXD1, GFAP
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| Effects of a polymorphism in the GFAP promoter on the age of onset and ambulatory disability in late-onset Alexander disease.
|
| Yoshida T, Mizuta I, Saito K, Ohara R, Kurisaki H, Ohnari K, Riku Y, Hayashi Y, Suzuki H, Shii H, Fujiwara Y, Yonezu T, Nagaishi A, Nakagawa M.
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| J Hum Genet 58(9):635-8. doi: 10.1038/jhg.2013.83. Epub 2013 Aug 1.
2013
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| 22 | GFAP
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| Correlational study of the serum levels of the glial fibrillary acidic protein and neurofilament proteins in Parkinson's disease patients.
|
| Su W, Chen HB, Li SH, Wu DY.
|
| Clin Neurol Neurosurg 114(4):372-5. doi: 10.1016/j.clineuro.2011.11.002. Epub 2011 Dec 27.
2012
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| 23 | ALXD1, GFAP
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| Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model.
|
| Wang L, Colodner KJ, Feany MB.
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| J Neurosci 31(8):2868-77.
2011
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| 24 | GFAP, PAX3
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| Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes.
|
| Liu Y, Zhu H, Liu M, Du J, Qian Y, Wang Y, Ding F, Gu X.
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| FEBS Lett 585(7):1014-20. Epub 2011 Mar 1.
2011
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| 25 | ALXD1, GFAP
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| GFAP mutations, age at onset, and clinical subtypes in Alexander disease.
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| Prust M, Wang J, Morizono H, Messing A, Brenner M, Gordon E, Hartka T, Sokohl A, Schiffmann R, Gordish-Dressman H, Albin R, Amartino H, Brockman K, Dinopoulos A, Dotti MT, Fain D, Fernandez R, Ferreira J, Fleming J, Gill D, Griebel M, Heilstedt H, Kaplan P, Lewis D, Nakagawa M, Pedersen R, Reddy A, Sawaishi Y, Schneider M, Sherr E, Takiyama Y, Wakabayashi K, Gorospe JR, Vanderver A.
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| Neurology 77(13):1287-94. Epub 2011 Sep 14.
2011
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| 26 | GFAP, SIN3A
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| Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.
|
| Cheng PY, Lin YP, Chen YL, Lee YC, Tai CC, Wang YT, Chen YJ, Kao CF, Yu J.
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| PLoS One 6(7):e22018. Epub 2011 Jul 11.
2011
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| 27 | GFAP
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| Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis.
|
| Axelsson M, Malmeström C, Nilsson S, Haghighi S, Rosengren L, Lycke J.
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| J Neurol 258(5):882-8. Epub 2011 Jan 1.
2011
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| 28 | ALXD1, GFAP
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| Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.
|
| Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD.
|
| Exp Cell Res 317(16):2252-66. doi: 10.1016/j.yexcr.2011.06.017. Epub 2011 Jul 2.
2011
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| 29 | ALXD1, GFAP
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| Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.
|
| Tang G, Perng MD, Wilk S, Quinlan R, Goldman JE.
|
| J Biol Chem 285(14):10527-37. Epub 2010 Jan 28.
2010
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| 30 | GFAP
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| Synergistic effect of retinoic acid and cytokines on the regulation of glial fibrillary acidic protein expression.
|
| Herrera F, Chen Q, Schubert D.
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| J Biol Chem 285(50):38915-22. Epub 2010 Sep 28.
2010
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| 31 | GFAP
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| GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.
|
| Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM.
|
| Development 137(2):313-21.
2010
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| 32 | ALXD1, CRYAB, GFAP
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| Suppression of GFAP toxicity by {alpha}B-crystallin in mouse models of Alexander disease.
|
| Hagemann TL, Boelens WC, Wawrousek EF, Messing A.
|
| Hum Mol Genet um Mol Genet. 2009 Jan 7. [Epub ahead of print]
2009
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| 33 | GFAP
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| Enhanced glial fibrillary acidic protein-delta expression in human astrocytic tumor.
|
| Choi KC, Kwak SE, Kim JE, Sheen SH, Kang TC.
|
| Neurosci Lett 463(3):182-7. Epub 2009 Jul 30.
2009
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| 34 | GFAP
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| Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies.
|
| Martinian L, Boer K, Middeldorp J, Hol EM, Sisodiya SM, Squier W, Aronica E, Thom M.
|
| Neuropathol Appl Neurobiol 35(4):394-405.
2009
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| 35 | GFAP
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| Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum.
|
| Silbereis J, Cheng E, Ganat YM, Ment LR, Vaccarino FM.
|
| Stem Cells 27(5):1152-63.
2009
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| 36 | GFAP, ALXD1
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| Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease.
|
| Bachetti T, Caroli F, Bocca P, Prigione I, Balbi P, Biancheri R, Filocamo M, Mariotti C, Pareyson D, Ravazzolo R, Ceccherini I.
|
| Eur J Hum Genet 16(4):462-70. Epub 2008 Jan 16. 2008
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| 37 | GFAP, ALXD1
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| Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways.
|
| Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE.
|
| Hum Mol Genet 17(11):1540-55. Epub 2008 Feb 14. 2008
|
| 38 | GFAP, ALXD1
|
| GFAP mutations and polymorphisms in 13 unrelated Italian patients affected by Alexander disease.
|
| Caroli F, Biancheri R, Seri M, Rossi A, Pessagno A, Bugiani M, Corsolini F, Savasta S, Romano S, Antonelli C, Romano A, Pareyson D, Gambero P, Uziel G, Ravazzolo R, Ceccherini I, Filocamo M.
|
| Clin Genet 72(5):427-33. Epub 2007 Sep 25. 2007
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| 39 | GFAP, SYNM, VIM
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| Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks.
|
| Jing R, Wilhelmsson U, Goodwill W, Li L, Pan Y, Pekny M, Skalli O.
|
| J Cell Sci 120(Pt 7):1267-77. Epub 2007 Mar 13.
2007
|
| 40 | ALXD1, GFAP
|
| A novel mutation in the GFAP gene in a familial adult onset Alexander disease.
|
| Salmaggi A, Botturi A, Lamperti E, Grisoli M, Fischetto R, Ceccherini I, Caroli F, Boiardi A.
|
| J Neurol 254(9):1278-80. Epub 2007 Aug 16. No abstract available.
2007
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| 41 | ALXD1, GFAP
|
| Novel mutations in exon 6 of the GFAP gene affect a highly conserved if motif in the rod domain 2B and are associated with early onset infantile Alexander disease.
|
| Hartmann H, Herchenbach J, Stephani U, Ledaal P, Donnerstag F, Lücke T, Das AM, Christen HJ, Hagedorn M, Meins M.
|
| Neuropediatrics 38(3):143-7.PMID: 17985264 2007
|
| 42 | ALXD1, GFAP
|
| Propensity for paternal inheritance of de novo mutations in Alexander disease.
|
| Li R, Johnson AB, Salomons GS, van der Knaap MS, Rodriguez D, Boespflug-Tanguy O, Gorospe JR, Goldman JE, Messing A, Brenner M.
|
| Hum Genet 119(1-2):137-44. Epub 2005 Dec 20. 2006
|
| 43 | ALXD1, GFAP, CRYAB, HSPB1
|
| The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27.
|
| Der Perng M, Su M, Wen SF, Li R, Gibbon T, Prescott AR, Brenner M, Quinlan RA.
|
| Am J Hum Genet 79(2):197-213. Epub 2006 Jun 12. 2006
|
| 44 | NFIX, GFAP
|
| Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.
|
| Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T.
|
| J Biol Chem 281(19):13126-33. Epub 2006 Mar 23. 2006
|
| 45 | ALXD1, GFAP
|
| An infantile-juvenile form of Alexander disease caused by a R79H mutation in GFAP.
|
| Asahina N, Okamoto T, Sudo A, Kanazawa N, Tsujino S, Saitoh S.
|
| Brain Dev 28(2):131-3. Epub 2005 Sep 15. 2006
|
| 46 | GFAP
|
| Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage.
|
| Triolo D, Dina G, Lorenzetti I, Malaguti M, Morana P, Del Carro U, Comi G, Messing A, Quattrini A, Previtali SC.
|
| J Cell Sci 119(Pt 19):3981-93. 2006
|
| 47 | GFAP, ALXD1
|
| Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease.
|
| Li R, Johnson AB, Salomons G, Goldman JE, Naidu S, Quinlan R, Cree B, Ruyle SZ, Banwell B, D'Hooghe M, Siebert JR, Rolf CM, Cox H, Reddy A, Gutierrez-Solana LG, Collins A, Weller RO, Messing A, van der Knaap MS, Brenner M.
|
| Ann Neurol 57(3):310-26. 2005
|
| 48 | GFAP
|
| Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAP.
|
| Singh R, Nielsen AL, Johansen MG, Jorgensen AL.
|
| Genomics 82(2):185-93. 2003
|
| 49 | GFAP, ALXD1
|
| Adult Alexander disease with autosomal dominant transmission: a distinct entity caused by mutation in the glial fibrillary acid protein gene.
|
| Stumpf E, Masson H, Duquette A, Berthelet F, McNabb J, Lortie A, Lesage J, Montplaisir J, Brais B, Cossette P.
|
| Arch Neurol 60(9):1307-12. 2003
|
| 50 | GFAP, ALXD1
|
| Juvenile Alexander disease with a novel mutation in glial fibrillary acidic protein gene.
|
| Sawaishi Y, Yano T, Takaku I, Takada G.
|
| Neurology 58(10):1541-3. 2002
|
| 51 | GFAP, ALXD1
|
| Identification of GFAP gene mutation in hereditary adult-onset Alexander's disease.
|
| Namekawa M, Takiyama Y, Aoki Y, Takayashiki N, Sakoe K, Shimazaki H, Taguchi T, Tanaka Y, Nishizawa M, Saito K, Matsubara Y, Nakano I.
|
| Ann Neurol 52(6):779-85. 2002
|
| 52 | ALXD1, GFAP
|
| Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.
|
| Brenner M, Johnson AB, Boespflug-Tanguy O, Rodriguez D, Goldman JE, Messing A.
|
| Nat Genet 27(1):117-20. 2001
|
| 53 | ALXD1, GFAP
|
| Infantile Alexander disease: spectrum of GFAP mutations and genotype-phenotype correlation.
|
| Rodriguez D, Gauthier F, Bertini E, Bugiani M, Brenner M, N'guyen S, Goizet C, Gelot A, Surtees R, Pedespan JM, Hernandorena X, Troncoso M, Uziel G, Messing A, Ponsot G, Pham-Dinh D, Dautigny A, Boespflug-Tanguy O.
|
| Am J Hum Genet 69(5):1134-40. 2001
|
| 54 | GFAP, S100A1
|
| Role of the C-terminal extension in the interaction of S100A1 with GFAP, tubulin, the S100A1- and S100B-inhibitory peptide, TRTK-12, and a peptide derived from p53, and the S100A1 inhibitory effect on GFAP polymerization.
|
| Garbuglia M, et al.
|
| Biochem Biophys Res Commun 254(1):36-41. 1999
|
| 55 | GFAP
|
| Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17.
|
| Isaacs A, et al.
|
| Genomics 51 : 152-154. 1998
|
| 56 | FAM104A, GFAP, NAP1L1, NUCB1, SERPINB8, PRPF4, SATB1, SRP14, PHLDA1, MED19, S100A16
|
| Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.
|
| Reddy PH, Stockburger E, Gillevet P, Tagle DA.
|
| Genomics 46(2):174-82. 1997
|
| 57 | GFAP
|
| Glial fibrillary acid protein, an astrocytic-specific marker, maps to human chromosome 17.
|
| Brownell E, et al.
|
| Genomics 10 : 1087-1089. 1991
|
| 58 | GFAP
|
| Mapping of glial fibrillary acidic protein gene (GFAP) to human chromosome 17.
|
| Minoshima S, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 2007. 1991
|
| 59 | GFAP
|
| Human glial fibrillary acidic protein : complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.
|
| Bongcam-Rudloff E, et al.
|
| Cancer Res 51 : 1553-1560. 1991
|